Semnan University of Medical Sciences

Research and Technology Vice Chancellor

Fakhri, Yadolah and Hassanzadeh, Vajihe and Oliveri Conti, Gea and Amanidaz, Nazak and Zandsalimi, Yahya and Moradi, Bigard and Rasouli Amirhajeloo, Leila and Keramati, Hassan (2016) Association between selenium level and bladder cancer; Systematic review and meta-analysis. International Journal of Pharmacy and Technology. pp. 4616-4628.

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    Bladder cancer is one of the common cancers in men. The different studies have shown different results on the effects of selenium on the risk of bladder cancer. The aim of this study was to determine the association between the selenium in serum,Toenail and supplements on the one hand and the risk of bladder cancer on the other. Doing a systematic review and meta-analysis of 9 studies (4 studies on the selenium level in the toenail,2 studies in serum and 3 studies in supplements),therefore,it was tried to achieve some exact results of the association between selenium and the bladder cancer risk. The results showed there is no publication error in the observational studies (Begger’s test =-0.71; 95% CI (-4,2.66). In the subgroups of selenium supplement,serum and Toenail,the heterogeneity was I² = 0% (P value = 0.81),I² = 0% (P value = 0.35) and I² = 1.47% (P value = 0.38) and overall I² = 63%(P value = 0.005),respectively. The risk ratio in the studies of selenium supplements,serum and Toenail was FEM = 1.02 (P value = 0.8),FEM = 0.3 (P value<0.001) and FEM = 0.85 (P value = 0.1) and in general FEM = 0.83 (P value = 0.01) respectively. The increase of selenium in supplements does not any effect on the increase or decrease of the bladder cancer (non-significant). The increase of selenium in serum and toenail reduces (significantly) the risk of bladder cancer in first case and (non-significantly) in second case. In general,the results of this study supported the lowering effect of selenium especially in serum on the risk of bladder cancer. © 2016,International Journal of Pharmacy and Technology. All rights reserved.

    Item Type: Article
    Subjects: R Medicine > R Medicine (General)
    Divisions: Faculty of Medical Sciences > School of Medicine
    Depositing User: Mr Vahab Moshtaghi
    Date Deposited: 07 May 2017 13:44
    Last Modified: 07 May 2017 13:44

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