Semnan University of Medical Sciences

Research and Technology Vice Chancellor

Shirzad, R and Shahrabi, S and Ahmadzadeh, A and Kampen, K.R and Shahjahani, M and Saki, N (2016) Signaling and molecular basis of bone marrow niche angiogenesis in leukemia. Clinical and Translational Oncology. pp. 957-971.

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    Abstract

    Angiogenesis, the process of blood vessel formation, is necessary for tissue survival in normal and pathologic conditions. Increased angiogenesis in BM niche is correlated with leukemia progression and resistance to treatment. Angiogenesis can interfere with disease progression and several angiogenic (such as vascular growth factors) as well as anti-angiogenic factors (i.e. angiostatin) can affect angiogenesis. Furthermore, miRs can affect the angiogenic process by inhibiting angiogenesis or increasing the expression of growth factors. Given the importance of angiogenesis in BM for maintenance of leukemic clones, recognition of angiogenic and anti-angiogenic factors and miRs as well as drug resistance mechanisms of leukemic blasts can improve the therapeutic strategies. We highlight the changes in angiogenic balance within the BM niche in different leukemia types. Moreover, we explored the pathways leading to drug resistance in relation to angiogenesis and attempted to assign interesting candidates for future research. KEYWORDS:Angiogenesis; Bone marrow; Drug resistance; Leukemia; Niche; miR

    Item Type: Article
    Subjects: R Medicine > R Medicine (General)
    Divisions: Faculty of Medical Sciences > School of Medicine
    Depositing User: Mr Vahab Moshtaghi
    Date Deposited: 22 Apr 2017 08:50
    Last Modified: 22 Apr 2017 08:50
    URI: http://eprints.semums.ac.ir/id/eprint/906

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