Semnan University of Medical Sciences

Research and Technology Vice Chancellor

Vafaei, Abbas Ali and Jezek, Karel and Bures, Jan and Fenton, Andre´ A. and Rashidy-Pour, Ali (2007) Post-training reversible inactivation of the rat's basolateral amygdala interferes with hippocampus-dependent place avoidance memory in a time-dependent manner. Neurobiology of Learning and Memory. pp. 87-93.

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    Abstract

    In this study, tetrodotoxin (TTX) inactivation was employed to evaluate the involvement of the rat's basolateral amygdala (BLA) in hippocampus-dependent spatial memory using a place avoidance learning task. Rats were trained in single 30 min session to avoid a 60 degrees segment of the stable circular (80-cm diameter) arena, entering which was punished by a mild shock. Bilateral injections of TTX or saline were made either immediately, 1 or 2h after training. Retention was tested 24h later in a 30 min extinction session. Retention was impaired when both BLA inactivated immediately or 1h after training, but not 2h after training. These data indicate that activity in the BLA, at least 60 min after training, is necessary for the post-training processing of a hippocampus-dependent place avoidance memory.

    Item Type: Article
    Subjects: R Medicine > R Medicine (General)
    Divisions: Faculty of Medical Sciences > School of Medicine
    Depositing User: Mr Vahab Moshtaghi
    Date Deposited: 05 Feb 2017 10:11
    Last Modified: 05 Feb 2017 10:11
    URI: http://eprints.semums.ac.ir/id/eprint/805

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