Semnan University of Medical Sciences

Research and Technology Vice Chancellor

Babaei, Mehdi and Abarghoei, Mitra Emmami and Ansari, Reza and Vafaei, Abbas Ali and Taherian, Abbas Ali and Akhavan, Maziar Mohammad and Toussy, Gafar and Mousavi, Shahrokh (2008) Antispasmodic effect of hydroalcoholic extract ofThymus vulgarison the guinea-pig ileum. Natural Product Research, 22 (13). pp. 1143-1150. ISSN 1478-6419

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    Abstract

    The effects of Thymus vulgaris hydroalcoholic extract on the contractile responses of the isolated guinea-pig ileum were investigated. Contraction changes in the terminal ileum of guinea pigs were monitored using a force displacement transducer amplifier connected to a physiograph. Thymus vulgaris extract inhibited the contractile responses in a dose-dependent manner and also decreased the amplitude of peristaltic waves. It is concluded that T. vulgaris has an antispasmodic action on guinea pig ileum by decreasing the amplitudes of the muscle contractions during peristalsis. The EC50 was calculated as 1.7 mg mL(-1). In guinea-pig ileum the extract led to an antispasmodic effect, possibly by affecting the anticholinergic and serotoninergic pathways.

    Item Type: Article
    Subjects: R Medicine > R Medicine (General)
    Divisions: Faculty of Medical Sciences > School of Medicine
    Depositing User: Mr Vahab Moshtaghi
    Date Deposited: 07 Jan 2017 14:33
    Last Modified: 07 Jan 2017 14:33
    URI: http://eprints.semums.ac.ir/id/eprint/749

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