Semnan University of Medical Sciences

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Abad, Atiyeh Taghavi-Khalil and Miladi-Gorji, Hossein and Bigdeli, Imanollah (2016) Effects of swimming exercise on morphine-induced reward and behavioral sensitization in maternally-separated rat pups in the conditioned place preference procedure. Neuroscience Letters, 631. pp. 79-84. ISSN 03043940

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    Abstract

    This study was designed to examine the effects of swimming exercise during adolescence on morphine-induced conditioned place preference (CPP) and behavioral sensitization in maternally separated male and female rat pups. Male Wistar rats were allowed to mate with female virgin Wistar rats. Pups were separated from the dam daily for 180min during postnatal days 2-14. All pups were weaned on day 21.The exercising pups were allowed to swim (60min/d, five days per a week, for 30days) during adolescence. Then, rat pups were tested for behavioral sensitization and the CPP induced by morphine. Maternal separation produced a significant increase in morphine-induced CPP in both sexes, behavioral sensitization in male pups and tolerance to morphine-induced motor activity in female pups. Swimmer pups separated from the dam exhibited a decrease in morphine-induced CPP in both sexes and behavioral sensitization in male pups than those of their control pups. The present results have shown that swimming exercise during adolescence may exert a protective effect against morphine-induced reward and behavioral sensitization in adult male and female rats following maternal separation.

    Item Type: Article
    Subjects: R Medicine > R Medicine (General)
    Divisions: Faculty of Medical Sciences > School of Medicine
    Depositing User: Admin User
    Date Deposited: 04 Sep 2016 08:01
    Last Modified: 04 Sep 2016 08:01
    URI: http://eprints.semums.ac.ir/id/eprint/69

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