Semnan University of Medical Sciences

Research and Technology Vice Chancellor

Faranoush, Mohammad and Jafarpoor, Ali and Ghorbani, Raheb and Rahmani, Mahbobeh and Jazebi, Mohammad and Shashaani, Tahereh and Danaie, Navid and Mohamadi, Gholamreza (2009) Correlation of thrombotic factor with bleeding severity in patient's with factor XI deficiency. Koomesh. pp. 55-61.

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    Introduction: Factor XI is a glycoprotein that important role in blood coagulation. The aim of this study is determine correlation of thrombotic factor and bleeding severity with factor XI deficiency. Materials and Methods: 24 patients with factor XI deficiency were included in this study. Following physical examination and interview, a questionnaire was filled for all the patients. A blood sample was collected for measurement of coagulation factors (II, V, VII, and VIII, IX, X, XI, XII, and XIII), fibrinogen, protein C, protein S, antithrombin III, PG20210A, factor V Leiden, MTHFR gene and Homocystein. Results: 54.2% and 45.8% of patients were male and female, respectively. Mean (±SD) age of patients was 27.2±13.6 (3-49) years. 45.8%, 29.2%, 25% of the patients showed mild, moderate and severe bleeding, respectively. Although, a significant positive correlation was observed between factor V and bleeding severity (P=0.033, r =0.491), there was no correlation between bleeding severity and other thrombotic factors. Conclusion: The findings showed that a positive correlation between factor XI deficiency and factor V. We need more studies as multicenter studies to detecting the relation of other thrombotic factors with bleeding severity in patients with factor XI deficiency Keywords: Factor XI, Thrombotic factor, Coagulation factor, Bleeding severity

    Item Type: Article
    Subjects: R Medicine > R Medicine (General)
    Divisions: Faculty of Medical Sciences > School of Medicine
    Depositing User: Mr Vahab Moshtaghi
    Date Deposited: 24 Dec 2016 07:35
    Last Modified: 24 Dec 2016 07:35

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