Semnan University of Medical Sciences

Research and Technology Vice Chancellor

Ebrahimi, Shima and Rashidy-Pour, Ali and Vafaei, Abbas A. and Akhavan, Maziar M. (2010) Central β-adrenergic receptors play an important role in the enhancing effect of voluntary exercise on learning and memory in rat. Behavioural Brain Research, 208 (1). pp. 189-193. ISSN 01664328

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    Abstract

    The beneficial effects of physical activity and exercise on brain functions such as improvement in learning and memory are well documented. The aim of this study was to examine the role of the beta-adrenergic system in voluntary exercise-induced enhancement of learning and memory in rat. In order to block the beta-adrenergic receptors, the animals were received propranolol (a beta-blocker), or nadolol (a peripherally acting beta-blocker) before each night of five consecutive nights of exercise. Then their learning and memory were tested on the water maze task using a two-trials-per-day for 5 consecutive days. A probe trial was performed 2 days after the last training day. Our results showed that propranolol, but not nadolol reversed the exercise-induced improvement in learning and memory in rat. Our findings indicate that central beta-adrenergic receptors play an important role in mediating the beneficial effects of voluntary exercise on learning and memory.

    Item Type: Article
    Subjects: R Medicine > R Medicine (General)
    Divisions: Faculty of Medical Sciences > School of Medicine
    Depositing User: Mr Vahab Moshtaghi
    Date Deposited: 21 Dec 2016 03:23
    Last Modified: 21 Dec 2016 03:23
    URI: http://eprints.semums.ac.ir/id/eprint/647

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