Semnan University of Medical Sciences

Research and Technology Vice Chancellor

Miladi Gorgi, Hosein and Safakhah, Hosein Ali and Haghighi, Sepinood (2010) Anxiolytic effects of the aqueous extracts of spinach leaves in mice. Scientific Journal of Kurdistan University of Medical Sciences. pp. 43-50.

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    Abstract

    ABSTRACT Background and aim: Previous studies have shown the effect of antioxidant properties of spinach on delaying the aging process of CNS and age related cognitive function and some neurodegenerative diseases. This study was designed to evaluate the anxiolytic effects of different doses of aqueous extracts of spinach leaves. Materials and Methods: This study included fifty male mice (Wt: 25-30 g) which were divided into three experimental and two control groups. Different doses of the spinach extract powder (0.05, 0.10 and 0.15 g/mice) were given to the experimental groups for one month. Also, one of the control groups received water and the other one sucrose 3% (w/v) for one month. In order to increase the activity and curiosity of the mice, they were put inside a box with black walls for five minutes. Then the animals were transferred to the elevated plus maze in regular time intervals and evaluated for standard indexes of anxiety reaction for five minutes. Results: The results of this study showed that percentage of open time was significantly increased in doses of 0.10 and 0.15, and the number of open arm entries was more with a dose of 0.15 g of spinach extract in comparison to the control group (P<0.05). Furthermore, no significant differences were found in the total number of arm entries between the groups. In comparison to the control group, the number of SAP was significantly reduced with doses of 0.10 and 0.15 g of spinach extract in the experimental group (P<0.05). Conclusion: It is concluded that higher doses of aqueous extract of spinach can decrease anxiety. Key words: Spinach, Anxiolytic, EPM (Elevated plus Maze), SAP (Stretched Attend Posture). Conflict of Interest: Nill Received: Apr 22, 2010 Accepted: Jul 2, 2010 Keywords: Spinach, Anxiolytic, EPM (Elevated plus Maze), SAP (Stretched Attend Posture).

    Item Type: Article
    Subjects: R Medicine > R Medicine (General)
    Divisions: Faculty of Medical Sciences > School of Medicine
    Depositing User: Mr Vahab Moshtaghi
    Date Deposited: 14 Dec 2016 02:15
    Last Modified: 14 Dec 2016 02:15
    URI: http://eprints.semums.ac.ir/id/eprint/625

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