Semnan University of Medical Sciences

Research and Technology Vice Chancellor

Nasri, Hamid and Mortazavi, Mojgan and Ghorbani, Ali and Shahbazian, Heshmatollah and Kheiri, Soleiman and Baradaran, Azar and Emami-Naieni, Afsoon and Saffari, Maryan and Mardani, Saeed and Momeni, Ali and Madihi, Yahya and Baradaran-Ghahfarokhi, Milad and Emami-Naieni, Afsoon and Saffari, Maryan and Mardani, Saeed and Momeni, Ali and Madihi, Yahya and Baradaran-Ghahfarokhi, Milad and Rafien-Kopaie, Mahmoud and Hedayati, Parvin and Baradaran, Shahzad and Ardalan, Mohammadreza and Sajjadieh, Shahram and Assarzadegan, Naziheh and Ahmadi Soleimani, Seyed Mohammad and Tamadon, Mohamad Reza (2012) Oxford-MEST classification in IgAnephropathy patinets: A report from Iran. Journal of Nephropathology, 1 (1). pp. 31-42. ISSN 22518363

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    BACKGROUND:There is a limited knowledge about the morphological features of IgA nephropathy (IgAN)in the middle east region. OBJECTIVES:The objective of this study was to evaluate the spectrum of histopathological findings in IgAN patients at our laboratory. PATIENTS AND METHODS:At this work, an observational study reported which was conducted on IgAN patients using the Oxford-MEST classification system. RESULTS:In this survey, of 102 patients 71.6 % were male. The mean age of the patients was 37.7 ± 13.6 years. Morphologic variables of MEST classification was as follows; M1: 90.2 %, E: 32 %, S: 67 % also,T in grads I and II were in 30% and 19% respectively, while 51% were in grade zero. A significant difference was observed in segmental glomerulosclerosis (P=0.003) and interstitial fibrosis/tubular atrophy frequency distribution (P= 0.045), between males and females . Furthermore, it was found that mesangial hypercellularity was more prevalent in yonger patients. Moreover, there was a significant correlation between serum creatinine and crescents (P<0.001). There was also significant correlation of serum creatinine with segmental glomerulosclerosis (P<0.001). CONCLUSIONS:Higher prevalence of segmental glomerulosclerosis and interstitial fibrosis/ tubular atrophy, as the two of, four variables of Oxford-MEST classification of IgAN in male patients further attests that male gender is a risk factor in this disease.In this study the significant correlation between serum creatinine and crescent was in an agreement with previous studies and suggests for the probable accomodation of extracapillary proliferation as a new variable in MEST system. KEYWORDS:Classification; Glomerulosclerosis; IgA nephropathy; Interstitial fibrosis; Proliferation; Tubular atrophy

    Item Type: Article
    Subjects: R Medicine > R Medicine (General)
    Divisions: Faculty of Medical Sciences > School of Medicine
    Depositing User: Mr Vahab Moshtaghi
    Date Deposited: 04 Dec 2016 11:17
    Last Modified: 04 Dec 2016 11:17

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