Semnan University of Medical Sciences

Research and Technology Vice Chancellor

Alimohammadian, M. H. and Jones, S. L. and Darabi, H. and Riazirad, F. and Ajdary, S. and Shabani, A. and Rezaee, M. A. and Mohebali, M. and Hosseini, Z. and Modabber, F. (2012) Assessment of Interferon- Levels and Leishmanin Skin Test Results in Persons Recovered for Leishmaniasis. American Journal of Tropical Medicine and Hygiene, 87 (1). pp. 70-75. ISSN 0002-9637

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    Abstract

    Patients who recover from leishmaniasis usually show development of strong immunity and induction of interferon-γ (IFN-γ) and delayed type hypersensitivity. In a randomized trial, we analyzed the IFN-γ response by using a Quantiferon-Leishmania assay against three Leishmania peptide antigens and compared it with results of the leishmanin skin test (LST) in persons residing in areas in Iran to which zoonotic cutaneous leishmaniasis (ZCL, 181 persons), anthroponotic cutaneous leishmaniasis (ACL, 104 persons), and zoonotic visceral leishmaniasis (ZVL, 67 persons) are endemic. The percentage of persons with an IFN-γ-positive response (> 0.2 IU/mL) to three antigens and the mean concentration of IFN-γ induced by the antigens were higher for persons from areas endemic for ZVL than for persons from areas endemic for ZCL and ACL. The percentage of persons with LST-positive results (≥ 5 mm indurations) was 99%, 94%, and 70% for areas with ZCL, ACL, and ZVL, respectively. Our data indicate that the LST is significantly more sensitive than IFN-γ levels in persons who have been cured of cutaneous leishmaniasis than in persons who have been cured of ZVL.

    Item Type: Article
    Subjects: R Medicine > R Medicine (General)
    Divisions: Faculty of Medical Sciences > School of Medicine
    Depositing User: Mr Vahab Moshtaghi
    Date Deposited: 26 Nov 2016 07:38
    Last Modified: 26 Nov 2016 07:38
    URI: http://eprints.semums.ac.ir/id/eprint/516

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