Semnan University of Medical Sciences

Research and Technology Vice Chancellor

Haghparast, Abbas and Omranifard, Alireza and Arezoomandan, Reza and Ghalandari-Shamami, Mohadeseh and Taslimi, Zahra and Vafaei, Abbas Ali and Rashidy-Pour, Ali (2013) Involvement of dopaminergic receptors of the rat nucleus accumbens in decreasing the conditioned place preference induced by lateral hypothalamus stimulation. Neuroscience Letters, 556. pp. 10-14. ISSN 03043940

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    Abstract

    tOur previous study showed that chemical stimulation of the lateral hypothalamus (LH) by carbachol canproduce conditioned place preference (CPP) in rats. Also, it has been indicated that orexin activates themesolimbic dopamine projecting neurons to the nucleus accumbens (NAc) and promotes the develop-ment of reward in rodents. Therefore, in this study, we tried to determine the role of intra-accumbal D1and D2 dopamine receptors in the development (acquisition) of reward-related behaviors induced bychemical stimulation of the LH. Eighty-eight adult male Wistar rats were unilaterally implanted by twoseparate cannulae into the LH and NAc. For chemical stimulation of LH, carbachol (250 nmol/0.5 �l saline)was microinjected once daily during 3-days conditioning phase (acquisition period) of CPP paradigm. Inthe next experiments, different doses of D1 receptor antagonist, SCH23390 (0.25, 1 and 4 �g/0.5 �l saline)or sulpiride (0.25, 1 and 4 �g/0.5 �l DMSO) as a D2 receptor antagonist were unilaterally microinjectedinto the NAc, 5 min prior to LH stimulation. One-way ANOVA showed that intra-accumbal administra-tion of SCH23390 or sulpiride can decrease the development of LH stimulation-induced CPP in the rats.However, this decrease is more effective after blockade of the D2 dopamine receptor in the NAc. It seemsthat the dopaminergic system in this area is involved in place preference induced by LH stimulation.

    Item Type: Article
    Subjects: R Medicine > R Medicine (General)
    Divisions: Faculty of Medical Sciences > School of Medicine
    Depositing User: Mr Vahab Moshtaghi
    Date Deposited: 12 Nov 2016 10:33
    Last Modified: 12 Nov 2016 10:33
    URI: http://eprints.semums.ac.ir/id/eprint/421

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