Semnan University of Medical Sciences

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Shahzamani, Mehran and Ghods, Kamran and Abedi, Gholamreza and Shahzamani, Peyman and Mirhoseini, Mahmood and Motamedi, Maryam (2015) Evaluation the effects of N-acetyl cysteine on pericardial adhesions in experimental rabbit models. Comparative Clinical Pathology, 24 (5). pp. 985-988. ISSN 1618-5641

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    Adhesions are one of the main causes of resternotomy complications. In this study, we evaluated the potential of N-acetyl cysteine irrigation in reducing or preventing pericardial adhesions after cardiac surgery in rabbits. Thirty rabbits were allocated randomly into two groups. Group C served as the control, and group N was the treatment group. After anaesthesia, sternotomy and opening a pericardial flap, the pericardial cavity was irrigated with 1 ml/kg saline (group C) or with 100 mg/kg of N-acetyl cysteine (group N). After 2 months, the sternum was re-opened and the site of operation evaluated for macroscopic and microscopic changes. Macroscopic evaluation revealed 40 % (n=6) with grade 1, 46%(n=7) with grade 2, and 13.3%(n=3)with grade 3 adhesions in group C. In group N, there were 60 % (n=9) with grade 0 (no adhesions) and 40%(n=6)with grade 1 adhesions. N-acetyl cysteine irrigation appears to significantly reduce macroscopic adhesions, and there was also a trend towards a reduced reaction microscopically; therefore, further studies are warranted.

    Item Type: Article
    Subjects: R Medicine > R Medicine (General)
    Divisions: Faculty of Medical Sciences > School of Medicine
    Depositing User: Mr Vahab Moshtaghi
    Date Deposited: 03 Oct 2016 15:05
    Last Modified: 03 Oct 2016 15:05

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