Semnan University of Medical Sciences

Research and Technology Vice Chancellor

Eghbali, A. and Khalilpour, A. and Taherahmadi, H. and Bagheri, B. (2019) Pantoprazole reduces serum ferritin in patients with thalassemia major and intermedia: A randomized, controlled study. Therapie. ISSN 00405957

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Abstract

Aim: Complications due to iron overload exert a problematic situation in patients with thalassemia. Proton pump inhibitors (PPIs) like pantoprazole are effective agents to reduce acid gastric acid secretion and perhaps to interrupt iron absorption in conditions with increased iron absorption. Our purpose was to study effects of pantoprazole addition to chelators on iron levels in patients with thalassemia major and intermedia. Methods: This randomized, controlled, and single center trial was performed on 60 patients with thalassemia major and intermedia in Amir Kabir hospital, Iran. Patients were randomized 1:1 to pantoprazole group (iron chelator plus pantoprazole) or control group (iron chelator) for 6 months. Serum ferritin was measured by ELISA. Iron content was measured by magnetic resonance imaging; heart T2* and liver T2*. Results: After 6 months of treatment, a significant reduction was seen in serum ferritin levels in the pantoprazole group (1444 ± 613 μg/mL to 1197 ± 956 μg/mL; P < 0.001). A further reduction was seen in patients with thalassmeia intermedia. There were no significant changes in myocardial T2* values in pantoprazole group compared to control group (23.6 ± 7.3 ms to 24.1 ± 6.4ms). Compared to the control group, pantoprazole therapy had no effect on hepatic T2* value (9.7 ± 2.3 ms to 9.8 ± 2.6 ms). However, between-group difference was significant (P < 0.05). Conclusion: Pantoprazole therapy for 6 months has benefits for reducing serum ferritin in patients with thalassemia major and intermedia. Pantoprazole addition to iron chelators seems safe. © 2019 Société française de pharmacologie et de thérapeutique

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medical Sciences > School of Medicine
Depositing User: Admin User
Date Deposited: 26 Mar 2019 08:29
Last Modified: 26 Mar 2019 08:29
URI: http://eprints.semums.ac.ir/id/eprint/1548

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