Semnan University of Medical Sciences

Research and Technology Vice Chancellor

Samimi, A. and Ghanavat, M. and Shahrabi, S. and Azizidoost, S. and Saki, N. (2019) Role of bone marrow adipocytes in leukemia and chemotherapy challenges. Cellular and Molecular Life Sciences. ISSN 1420682X

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    Abstract

    Adipose tissue (AT) is an extramedullary reservoir of normal hematopoietic stem cells (HSCs). Adipocytes prevent the production of normal HSCs via secretion of inflammatory factors, and adipocyte-derived free fatty acids may contribute to the development and progression of leukemia via providing energy for leukemic cells. In addition, adipocytes are able to metabolize and inactivate therapeutic agents, reducing the concentrations of active drugs in adipocyte-rich microenvironments. The aim of this study was to detect the role of adipocytes in the progression and treatment of leukemia. Relevant literature was identified through a PubMed search (2000–2018) of English-language papers using the following terms: leukemia, adipocyte, leukemic stem cell, chemotherapy, and bone marrow. Findings suggest the striking interplay between leukemic cells and adipocytes to create a unique microenvironment supporting the metabolic demands and survival of leukemic cells. Based on these findings, targeting lipid metabolism of leukemic cells and adipocytes in combination with standard therapeutic agents might present novel treatment options. © 2019, Springer Nature Switzerland AG.

    Item Type: Article
    Subjects: R Medicine > R Medicine (General)
    Divisions: Faculty of Medical Sciences > School of Medicine
    Depositing User: Admin User
    Date Deposited: 18 Mar 2019 13:40
    Last Modified: 18 Mar 2019 13:40
    URI: http://eprints.semums.ac.ir/id/eprint/1539

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