Semnan University of Medical Sciences

Research and Technology Vice Chancellor

Samadani, Ali Akbar and Norollahi, Seyedeh Elham and Rashidy-Pour, Ali and Mansourghanaei, Fariborz and Nemati, Shadman and Joukar, Farahnaz and Afshar, Amir Mahmoud and Ghazanfari, Sahar and Safizadeh, Mahsa and Rostami, Pooya and Gatei, Magtouf H (2018) Cancer signaling pathways with a therapeutic approach: An overview in epigenetic regulations of cancer stem cells. Biomedicine and Pharmacotherapy, 108. pp. 590-599. ISSN 07533322

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One of the most important issues in cancer progression is caner stem cells (CSCs) which have illustrated that the bulk tumors can arise from a special combination of cells. Remarkably, it has been proposed to be a notable and strong factor in carcinogenesis and tumorogenesis and also is a key parameter of therapeutic resistance. In this way, recent findings have shown the key roles of epigenetic regulations in cancer development.Considerably, epigenetic regulations of gene expression is an active and dynamic process including histone modification, DNA methylation and chromatin remodeling with a reversible trait.Meaningly, recent and novel findings have described the significance of epigenetic regulatory proteins from divers features comprising tumorogenesis,stem cell proliferation and carcinogenesis. Evidently, abnormal epigenetic regulations is directly related with many serious disorders particularly different cancers. We here review a discussion of how the deregulation of eclectic pathways containing Sonic Hedgehog (SHH), WNT, Beta catenin and NOTCH can help to carcinogenesis specially focusing to survival and maintenance of CSCs in therapeutic approach. © 2018 Elsevier Masson SAS

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medical Sciences > School of Medicine
Depositing User: Admin User
Date Deposited: 31 Dec 2018 13:05
Last Modified: 31 Dec 2018 13:05

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