Semnan University of Medical Sciences

Research and Technology Vice Chancellor

Soheilifar, Mohammad Hasan and Taheri, Ramezan Ali and Zolfaghari Emameh, Reza and Moshtaghian, Abdolvahab and Kooshki, Hamid and Motie, Mohammad Reza (2018) Molecular Landscape in Alveolar Soft Part Sarcoma: Implications for Molecular Targeted Therapy. Biomedicine & Pharmacotherapy, 103. pp. 889-896. ISSN 07533322

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    Abstract

    Alveolar soft part sarcoma (ASPS) is a highly aggressive rare soft tissue sarcoma (STS) with poor prognosis especially in the metastatic form. ASPS is resistant to standard chemotherapy. Although, early diagnosis and surgical resection of operable tumor could lead to improved patient survival but novel treatment options are needed for advanced (metastatic) ASPS. This malignancy exhibits highly angiogenic behavior which reflects hyper-activation and over expression of angiogenic factors. Understanding the molecular events in this type of sarcoma is important in finding novel molecular based targeted therapies. We aim to review molecular aspects of ASPS growth and treatment. KEYWORDS:Alveolar soft part sarcoma; Drug resistance; Molecular targeted therapy; Tyrosine kinase inhibitor

    Item Type: Article
    Subjects: R Medicine > R Medicine (General)
    Divisions: Faculty of Medical Sciences > School of Medicine
    Depositing User: Mr Vahab Moshtaghi
    Date Deposited: 10 Jul 2018 10:39
    Last Modified: 10 Jul 2018 10:44
    URI: http://eprints.semums.ac.ir/id/eprint/1408

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