Semnan University of Medical Sciences

Research and Technology Vice Chancellor

Tashvighi, Maryam and Mehrvar, Azim and Hedayati Asl, Amir Abbas and Mehrvar, Narjes and Ghorbani, Raheb and Naderi, Ali and Alebouyeh, Mardawig and Sattary, Erfan and Niktoreh Mofrad, Naghmeh and Qaddoumi, Ibrahim and Faranoush, Mohammad (2018) Treatment challenges and outcomes for pediatric intracranial ependymoma at a single institution in Iran. Pediatric Hematology and Oncology, 35 (1). pp. 60-75. ISSN 0888-0018

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BACKGROUND: The scarcity of information on pediatric ependymoma in Iran motivated this study. Our main objectives were to determine outcomes, identify clinical management challenges at a nongovernment hospital in Iran, and devise guidelines for improving care. PROCEDURE: A retrospective chart review was performed for pediatric patients with ependymoma who were younger than 15 years and treated at MPCTRC between 2007 and 2015. Records included patient demographics, treatment regimens used, duration of follow-up, and outcomes. Clinical outcomes [ie, 3-year overall survival (OS) and progression-free survival (PFS)] were determined based on the age at diagnosis (younger or older than 3 years) by using the Kaplan-Meier method. RESULTS: In total, 73 eligible patients were enrolled; 20 patients were in the younger group, and 53 were in the older group. The majority (91.8%, n = 67) of patients underwent initial gross-total or partial surgical resection, and 6 (8.2%) had a biopsy. Twenty-one patients experienced ependymoma recurrence. The median time to relapse was 1 year. The median duration of follow-up and PFS were 25 and 17 months, respectively. The 3-year OS and PFS were 61% and 59.5%, respectively. At the time of this project, 27 patients had died, and 35 were alive with no evidence of disease. CONCLUSION: Our study demonstrated inferior outcomes of Iranian children with ependymoma. To improve our care for these children, a paradigm shift must occur that includes radiation therapy as standard of care, second-look surgery, a multidisciplinary team approach, and potentially twinning initiatives. KEYWORDS: Disease management; Iran; ependymoma; pediatric oncology

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medical Sciences > School of Medicine
Depositing User: Mr Vahab Moshtaghi
Date Deposited: 30 Apr 2018 14:04
Last Modified: 23 May 2018 09:56

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