Semnan University of Medical Sciences

Research and Technology Vice Chancellor

Firoozabadi, Ali and Kolouri, Sepideh and Zarshenas, Mohammad M. and Salehi, Alireza and Mosavat, Seyed Hamdollah and Dastgheib, Seyed Ali (2017) Efficacy of a freeze-dried aqueous extract of Nepeta menthoides Boiss. & Buhse in the treatment of anxiety in patients with depression: A double-blind, randomized, controlled trial. Journal of Herbal Medicine, 10. pp. 17-23. ISSN 22108033

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Abstract

Objective:To assess the efficacy and safety of a freeze dried, aqueous extract of Nepeta menthoides Boiss. & Buhse (N. menthoides) in reducing anxiety in patients suffering from depression. Method: A two–armed, double-blind, randomized, controlled trial was conducted with 70 patients suffering from anxiety and depression. Participants were randomly assigned to two groups, receiving capsules of either N. menthoides or sertraline for four weeks. The Beck anxiety inventory (BAI) score together with side effects of the intervention were evaluated at baseline and then every two weeks up to the sixth week (i.e. two weeks after cessation of the intervention). In addition, Folin-Ciocalteu and Dowd methods were utilized to determine total phenolic and flavonoid contents of the N. menthoides extract. Results: The N. menthoides group demonstrated: (a) a greater reduction of BAI scores as compared to the sertraline group in the 2nd (16.52 ± 8.07 vs. 21.38 ± 10.98, P = 0.04) and 4th (11.55 ± 6.74 vs. 20.47 ± 11.53, P < 0.0001) weeks, (b) a lower recurrence rate, with BAI scores of 11.06 ± 7.36 in the N. menthoides vs. 24.73 ± 12.93 in the sertraline group, two weeks after finishing the intervention (P < 0.0001), and (c) fewer side effects when compared to those of the sertraline group. Twelve patients reported severe side effects from the intervention, with only one of these belonging to the N. menthoides group. The total phenolic and flavonoid contents of the N. menthoides extract were 127.09 ± 0.43 mg Gallic acid equivalent/g and 16.93 ± 0.09 mg Quercetin/g of the extract, respectively. Conclusion: The anxiolytic effects of N. menthoides, its lower symptom recurrence rate and its lesser side effects make this herb a potential alternative treatment for anxiety in patients with depression. The presence of polyphenols and flavonoids in the extract might be at least partially responsible for these clinical effects.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medical Sciences > School of Medicine
Depositing User: Mr Vahab Moshtaghi
Date Deposited: 22 Apr 2018 02:42
Last Modified: 21 May 2018 04:03
URI: http://eprints.semums.ac.ir/id/eprint/1212

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