Semnan University of Medical Sciences

Research and Technology Vice Chancellor

Faghihi, Gita and Fatemi-Tabaei, Saghi and Abtahi-Naeini, Bahareh and Siadat, Amir Hossein and Sadeghian, Giti and Nilforoushzadeh, Mohammad Ali and Mohamadian-shoeili, Hamed (2017) The effectiveness of a 5% retinoic acid peel combined with microdermabrasion for facial photoaging: A randomized, double-blind, placebo-controlled clinical trial. Dermatology Research and Practice. pp. 1-7.

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Abstract

Background . Tretinoin has been shown to improve photoaged skin. This study was designed to evaluate the efficacy and tolerability of a 5% retinoic acid peel combined with microdermabrasion for facial photoaging. Materials and Methods . Forty-five patients, aged 35–70, affected by moderate-to-severe photodamage were enrolled in this trial. All patients received 3 sessions of full facial microdermabrasion and 3 sessions of either 5% retinoic acid peel or placebo after the microdermabrasion. Efficacy was measured using the Glogau scale. Patients were assessed at 2 weeks and 1, 2, and 6 months after treatment initiation. Results . The mean ± SD age of participants was 49.55±11.61 years, and the majorities (73.3%) were female. Between 1 month and 2 months, participants reported slight but statistically significant improvements for all parameters ( P<0.001 ). In terms of adverse effects, there were statistically significant differences reported between the 5% retinoic acid peel groups and the control group ( P<0.001 ). The majority of adverse effects reported in the study were described as mild and transient. Conclusion . This study demonstrated that 5% retinoic acid peel cream combined with microdermabrasion was safe and effective in the treatment of photoaging in the Iranian population. This trial is registered with IRCT2015121112782N8 .

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medical Sciences > School of Medicine
Depositing User: Mr Vahab Moshtaghi
Date Deposited: 16 Jul 2017 22:47
Last Modified: 21 May 2018 04:01
URI: http://eprints.semums.ac.ir/id/eprint/1187

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