Semnan University of Medical Sciences

Research and Technology Vice Chancellor

Nazari, Hossein and Bidokhty, Shayan and Mohammadi, Abolfazl and Jafari, Maryam and Taherian, Abbas Ali (2016) Antinociceptive effects of aqeous extract Launaea acanthodes gum in mice. Koomesh. pp. 154-163.

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    Introduction: Previous studies indicated that Launaea acanthodes (LA) can be effective against epilepsy, nervous disorder, local and articular pain and convulsion disorders. The aim of this study was to assessment the antinoceceptive effects of LA on peripheral and visceral pain in mice by using hot plate (HP), tail flick (TF), formalin (FT) and writhing (WR) tests. Materials and Methods: In this study 160 young adult male albino mice (25-30 g) were used (n = 8 in each group). Aqueous extract of LA gum (50, 100, and 200 mg/Kg IP) and saline (SAL) were injected 30 min before the pain evaluation tests. Acute and chronic pain was assessed by HP, TF and FT models and visceral pain was assessed by writhing test. Results: Results indicated that LA has analgesic effects (P< 0.05) in comparison with the control and saline groups and higher dose of LA was more effective (P< 0.001). Conclusion: The above findings showed that LA have modulatory effects on acute, chronic and visceral pain Keywords: Launaea acanthodes, Peripheral Pain, Visceral Pain, Mice

    Item Type: Article
    Subjects: R Medicine > R Medicine (General)
    Divisions: Faculty of Medical Sciences > School of Medicine
    Depositing User: Mr Vahab Moshtaghi
    Date Deposited: 03 Jul 2017 12:42
    Last Modified: 03 Jul 2017 12:42

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