Semnan University of Medical Sciences

Research and Technology Vice Chancellor

T Shamsabadi, Fatemeh and Akbari Eidgahi , Mohamad Reza and Mehrbod, Parvaneh and Daneshvar, Nasibeh and Nazariah Allaudin, Zeenathul and Yamchi, Ahad and Shahbazi, Majid (2016) Survivin, a Promising Gene for Targeted Cancer Treatment. Asian Pacific journal of cancer prevention : APJCP. pp. 3711-3719.

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    Drawbacks of conventional cancer treatments, with lack of specificity and cytotoxicity using current approaches, underlies the necessity for development of a novel approach, gene-directed cancer therapy. This has provided novel technological opportunities in vitro and in vivo. This review focuses on a member of an apoptosis inhibitor family, survivin, as a valuable target. Not only the gene but also its promoter are applicable in this context. This article is based on a literature survey, with especial attention to RNA interference as well as tumor- specific promoter action. The search engine and databases utilized were Science direct, PubMed, MEDLINE and Google. In addition to cell-cycle modulation, apoptosis inhibition, interaction in cell-signaling pathways, cancer-selective expression, survivin also may be considered as specific target through its promoter as a novel treatment for cancer. Our purpose in writing this article was to create awareness in researchers, emphasizing relation of survivin gene expression to potential cancer treatment. The principal result and major conclusion of this manuscript are that survivin structure, biological functions and applications of RNA interference systems as well as tumor-specific promoter activity are of major interest for cancer gene therapy.

    Item Type: Article
    Subjects: R Medicine > R Medicine (General)
    Divisions: Faculty of Medical Sciences > School of Medicine
    Depositing User: Mr Vahab Moshtaghi
    Date Deposited: 25 Jun 2017 13:17
    Last Modified: 25 Jun 2017 13:17

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